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Cellular Respiration and Carcinogenesis informs the reader about both basic and recent research in the field of cellular respiration and the effects of its dysfunction, alteration or attenuation on the development of cancer. This masterfully compiled text by leading experts in the field, offers the reader a fundamental understanding about how oxygen sensing and/or availability, programmed cell death, immune recognition and response and glucose metabolism are intimately linked with the two major mechanisms or pathways of cellular respiration; oxidative phosphorylation and glycolysis. The editors and contributing authors proficiently and unequivocally address the effects of dysfunction of the mitochondrial oxidative phosphorylation/glycolysis (cellular respiration) mechanisms and pathways on the development of cancer. While it remains true that there are no universal truths in cancer, Cellular Respiration and Carcinogenesis opens the dialogue that the etiology of cancer can usually be associated with and significantly attributed to the failure of one or multiple pathways of oxidative phosphorylation to normally burn fuel to generate energy, vis-à-vis the Warburg hypothesis. Keeping with its cutting-edge nature, Cellular Respiration and Carcinogenesis provides the first glimpse of cautionary evidence based counterbalance to the recent and rapidly proliferating notion that utilization of fuel primarily via glycolysis is a hallmark of cancer development. About the Editors: Shireesh P.Apte, Ph.D has 10+ years experience in the pharmaceutical industry researching and formulating anti-cancer drugs. He holds one US patent and has 10+ related publications. He is a member of the US Pharmacopoeia excipients expert committee. Rangaprasad Sarangarajan, Ph.D. has over 10 years of research experience in an academic setting with extensive publications in areas of pharmacology & toxicology with focus on cancer treatment. He is active member of various professional organizations including the Society of Toxicology, American Society for Pharmacology & Toxicology and Pan American Society for Pigment Cell Research.

Histology. Cytology --- cytologie --- histologie

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General microbiology --- Histology. Cytology --- microbiologie --- cytologie --- histologie

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Cancer is a major cause of human morbidity and mortality worldwide. Despite decades of basic and clinical research, the outcome for many cancer patients is still dismal. Although the existence of "stem-like" cells in cancer was hypothesized more than 150 years ago, recent discoveries have the potential to revolutionize cancer therapy. In particular, we now know that many cancers contain a fraction of self-renewing, drug- and radiation-resistant cells (cancer stem cells or cancer-initiating cells) and it is these cells and not the major bulk of the tissue that are the root cause for cancer initiation, relapse and metastasis. In a single volume, Stem Cells and Cancer offers up-to-date information about the role of stem cells in the development of normal and cancerous tissue, the mechanisms that differentiate normal from cancerous functions, and the use of these findings in developing mechanism-based therapies across all major types of cancer. It provides timely, cutting-edge information about cancer stem cells from the perspectives of both the basic and clinical sciences.

Histology. Cytology --- Oncology. Neoplasms --- stamcellen --- oncologie --- cytologie --- histologie

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Histology. Cytology --- Oncology. Neoplasms --- stamcellen --- oncologie --- cytologie --- histologie

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Histology. Cytology --- General biochemistry --- General biophysics --- biofysica --- biochemie --- cytologie --- histologie